Traveling can be exciting, but it can also be stressful for your body. From jet lag to motion sickness, there are a variety of health issues that can arise while on the road.

To be prepared, it’s important to pack a few essential over-the-counter (OTC) medications that can help alleviate common travel-related ailments. While you are in your pre-planning phase, be prepared by having a full travel medicine list.

You can begin with these OTC medications that should be in every traveler’s first-aid kit. You can also click here to read what you should bring if you are traveling with children.

Remember, with any over the counter medication you choose to take, it is IMPORTANT to discuss with your health care provider to ensure that it is safe for you to take. Note: Products suggested below are items that can be commonly used in the event of a first-aid situation. Please discuss with your health care provider regarding it’s safety use.

Here are some must-have OTC medications to pack for your next trip. Click here if you want to learn more about how to pack your medications correctly.

Pain relievers

Whether it’s a headache from jet lag, headaches, or sore muscles from carrying heavy luggage, pain relievers like ibuprofen or acetaminophen can come in handy while traveling. These medications can help alleviate pain and reduce inflammation, making it easier to enjoy your trip. It also has the added benefit of being a fever-reducer as well. Just be sure to follow the recommended dosage and check with your doctor if you have any underlying health conditions or are taking other medications. I would recommend bringing both so you have the option to alternate between the two.

  1. Acetaminophen (Tyelnol)
  2. Ibuprofen (Advil)
Tylenol (Travel Size)
Ibuprofen (Travel Size)
OTC Pain Relievers
Tylenol Extra Strength Caplets with 500 mg Acetaminophen, Pain Reliever & Fever Reducer, 10 ct
Advil Pain Reliever and Fever Reducer, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief - 10 Coated Tablets
Price
$1.88
$3.99
Buy Here
Tylenol (Travel Size)
OTC Pain Relievers
Tylenol Extra Strength Caplets with 500 mg Acetaminophen, Pain Reliever & Fever Reducer, 10 ct
Price
$1.88
Buy Here
Ibuprofen (Travel Size)
OTC Pain Relievers
Advil Pain Reliever and Fever Reducer, Pain Relief Medicine with Ibuprofen 200mg for Headache, Backache, Menstrual Pain and Joint Pain Relief - 10 Coated Tablets
Price
$3.99
Buy Here

Antihistamines for allergies

If you suffer from allergies while traveling, antihistamines can be a lifesaver. They can help relieve symptoms like sneezing, runny nose, itchy eyes, and nausea. Just be aware that some antihistamines can cause drowsiness, so it’s best to take them when you have some downtime or before bed. For travelers with known food-allergies, it would be beneficial to discuss with your health care provider to obtain an epi-pen. Always have an Allergy-Action plan.

3. Benadryl (fast acting antihistamine, for immediate relief)
4. Zyrtec (for general allergen control)
5. Flonase (can help with sneezing or runny nose)

Benadryl
Zyrtec
Flonase
OTC Allergy Medications
Benadryl Ultratabs Antihistamine Allergy Relief with Diphenhydramine HCl, 24 Count
Zyrtec 24 Hour Allergy Relief Tablets, 10 mg Cetirizine HCl Antihistamine Allergy Medicine, 14 ct
Flonase Allergy Relief Nasal Spray, 24-Hour Non-Drowsy Multi-Symptom Relief - 72 Sprays plus Bonus Pack of Tissues
Price
$5.99
$14.99
$17.49
Buy Here
Benadryl
OTC Allergy Medications
Benadryl Ultratabs Antihistamine Allergy Relief with Diphenhydramine HCl, 24 Count
Price
$5.99
Buy Here
Zyrtec
OTC Allergy Medications
Zyrtec 24 Hour Allergy Relief Tablets, 10 mg Cetirizine HCl Antihistamine Allergy Medicine, 14 ct
Price
$14.99
Buy Here
Flonase
OTC Allergy Medications
Flonase Allergy Relief Nasal Spray, 24-Hour Non-Drowsy Multi-Symptom Relief - 72 Sprays plus Bonus Pack of Tissues
Price
$17.49
Buy Here

Anti-diarrheal medication

One of the most common health issues travelers face is diarrhea, which can be caused by a variety of factors including changes in diet, water, and hygiene. OTC Anti-motility agents work by slowing down the movement of the intestines and can provide relief from symptoms like abdominal cramping and loose stools. However, it’s important to note that if you have severe diarrhea or bloody stools, you should seek medical attention immediately. You may discuss with a travel health specialist or your primary health doctor if it would be appropriate to travel with an antibiotic in the event of Travelers’ diarrhea.

6. Pepto bismol or Imodium

Travel Size Pepto Bismol
Travel Size Imodium
OTC Anti-diarrheal
Diarrhea Relief, 12 Chewable Tablets
Imodium AD Diarrhea Relief Caplets -Loperamide Hydrochloride Anti-Diarrheal Medicine (294314), Blue, 6 Count
Price
$8.08
$4.59
Buy Here
Travel Size Pepto Bismol
OTC Anti-diarrheal
Diarrhea Relief, 12 Chewable Tablets
Price
$8.08
Buy Here
Travel Size Imodium
OTC Anti-diarrheal
Imodium AD Diarrhea Relief Caplets -Loperamide Hydrochloride Anti-Diarrheal Medicine (294314), Blue, 6 Count
Price
$4.59
Buy Here

Constipation

For many travelers, traveling can take a toll on a person’s circadian rhythm. With new foods, inadequate fluid intake, lack of fiber, constipation and bloating can be bothersome. Traveling with a fiber supplement and/or a stool softener can help alleviate feeling full.

7. Metamucil (fiber supplement)
8. Miralax (mild laxative)

Metamucil
Miralax
OTC Medications for Constipation
Metamucil On-The-Go, Daily Psyllium Husk Powder Supplement, Sugar-Free Powder, 4-in-1 Fiber for Digestive Health, Orange Flavored Drink, 44 Packets
MiraLAX Gentle Constipation Relief Laxative Powder, Stool Softener with PEG 3350, No Harsh Side Effects, Single Dose Mix-In Pax with Mixing Stirrers, Travel Pack, 10 Dose
Price
$20.89
$19.99
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Metamucil
OTC Medications for Constipation
Metamucil On-The-Go, Daily Psyllium Husk Powder Supplement, Sugar-Free Powder, 4-in-1 Fiber for Digestive Health, Orange Flavored Drink, 44 Packets
Price
$20.89
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Miralax
OTC Medications for Constipation
MiraLAX Gentle Constipation Relief Laxative Powder, Stool Softener with PEG 3350, No Harsh Side Effects, Single Dose Mix-In Pax with Mixing Stirrers, Travel Pack, 10 Dose
Price
$19.99
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Medications for motion sickness

If you’re prone to motion sickness, it’s important to pack medication to prevent or alleviate symptoms. If you are prone to nausea or vomiting while on a boat, plane, or long car ride, consider taking these medications at least an hour beforehand. It’s also important to note that some medications can cause drowsiness, so be sure to read the label and plan accordingly.

Alternatively, you may also discuss with your healthcare provider to see if scopolamine patches would be an option. This requires a prescription. Usually, these patches are not recommended for children or adults who have a form of glaucoma, so please discuss with your health care provider.

9. Dramamine or Bonine

Bonine
Dramamine
OTC Motion Sickness Medications
Non-Drowsy Bonine for Motion Sickness Relief, Sea Sickness, Car Sickness, Nausea, & Vomiting - Meclizine HCI 25mg, Travel-Sized - 16ct Raspberry Chewable Tablets (Packaging May Vary)
Dramamine Motion Sickness Relief Less Drowsey Formula, 8 Count (Pack of 1)
Price
$5.94
$3.90
Buy Here
Bonine
OTC Motion Sickness Medications
Non-Drowsy Bonine for Motion Sickness Relief, Sea Sickness, Car Sickness, Nausea, & Vomiting - Meclizine HCI 25mg, Travel-Sized - 16ct Raspberry Chewable Tablets (Packaging May Vary)
Price
$5.94
Buy Here
Dramamine
OTC Motion Sickness Medications
Dramamine Motion Sickness Relief Less Drowsey Formula, 8 Count (Pack of 1)
Price
$3.90
Buy Here

Topical creams for skin issues

You want to be prepared for any skin flare-ups caused by bug bites, rashes, cuts, or sunburns. Having these OTC items can help alleviate some of the most common skin concerns during your travel.

10. Hydrocortisone cream (for bug bite itch relief)
11. Antibiotic cream for wounds or cuts (Neosporin, Bacitracin)
12. Aloe gel for sunburns

Hydrocortisone (1%) Cream
Neosporin Cream
Bacitracin Cream
Aloe Gel
OTC Topical Creams
Cortizone 10 Maximum Strength Sensitive Skin Anti-Itch Cream, 1% Hydrocortisone, 2 oz.
Neosporin Original Antibiotic Ointment, 24-Hour Infection Prevention for Minor Wound, 1 oz
CareAll Bacitracin Antibiotic Zinc Ointment 0.9gr Foil Packet (25 Pack). First Aid Ointment to Prevent and Heal Infections for Minor Cuts, Scrapes and Burns.
Aloderma 99% Organic Aloe Vera Gel Made within 12 Hours of Harvest, Refreshing Travel Size Aloe Vera Gel for Face & Body, Cooling, Soothing Instant Relief for Skin & Sunburn, Hydrating Aloe Gel, 1.5oz
Price
$8.48
$8.48
$5.25
$7.99
Buy Here
Hydrocortisone (1%) Cream
OTC Topical Creams
Cortizone 10 Maximum Strength Sensitive Skin Anti-Itch Cream, 1% Hydrocortisone, 2 oz.
Price
$8.48
Buy Here
Neosporin Cream
OTC Topical Creams
Neosporin Original Antibiotic Ointment, 24-Hour Infection Prevention for Minor Wound, 1 oz
Price
$8.48
Buy Here
Bacitracin Cream
OTC Topical Creams
CareAll Bacitracin Antibiotic Zinc Ointment 0.9gr Foil Packet (25 Pack). First Aid Ointment to Prevent and Heal Infections for Minor Cuts, Scrapes and Burns.
Price
$5.25
Buy Here
Aloe Gel
OTC Topical Creams
Aloderma 99% Organic Aloe Vera Gel Made within 12 Hours of Harvest, Refreshing Travel Size Aloe Vera Gel for Face & Body, Cooling, Soothing Instant Relief for Skin & Sunburn, Hydrating Aloe Gel, 1.5oz
Price
$7.99
Buy Here

Cough, congestion, cold medicine

Access to a local pharmacy may be difficult to find depending on where you are. When you are sick with a cold, the last thing you would want to do is leave your bed and find a pharmacy. Having these over-the-counter cold relief medications can save you time and effort in the event you need immediate relief for your congestion or sore throat.

13. Dayquil/Nyquil
14. Cough drops or throat lozanges

Cough Drops
Dayquil/Nyquil
OTC Cold Relief Medicines
Ricola Dual Action Honey Lemon Cough Drops, 19 Count
VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps
Price
$14.99
$16.97
Buy Here
Cough Drops
OTC Cold Relief Medicines
Ricola Dual Action Honey Lemon Cough Drops, 19 Count
Price
$14.99
Buy Here
Dayquil/Nyquil
OTC Cold Relief Medicines
VICKS DayQuil & NyQuil SEVERE Co-Pack, Cold & Flu Medicine, Powerful Relief for Headache, Fever, Sore Throat, Minor Aches & Pains, Congestion, Sinus Pressure, Stuffy Nose, and Cough, 48 LiquiCaps
Price
$16.97
Buy Here

Antacids

New foods and spicy foods could cause heartburn. If you are prone to heartburn, consider bringing an antacid with you. It is best taken before your meals to prevent any discomfort you may feel during and after you finish your meal.

15. Calcium carbonate (Tums) or Pepcid

Tums
Zantac
OTC Antacid Medications
TUMS Tablets, 8 Count (Pack of 3)
Zantac 360 Maximum Strength Tablets, 8 Count, Heartburn Prevention and Relief, 20 mg Tablets
Price
$2.68
$9.98
Buy Here
Tums
OTC Antacid Medications
TUMS Tablets, 8 Count (Pack of 3)
Price
$2.68
Buy Here
Zantac
OTC Antacid Medications
Zantac 360 Maximum Strength Tablets, 8 Count, Heartburn Prevention and Relief, 20 mg Tablets
Price
$9.98
Buy Here

TravelHealthInsider.com may earn a commission on purchases made through these links at no additional cost to you. We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com. These product recommendations are provided for informational purposes only and should not be considered an endorsement or guarantee of suitability. Individuals are encouraged to conduct their own due diligence and discuss any medication use with their health provider to ensure the products meet their specific needs.

Post last updated: 1/4/2025

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